Department(s): Department of Neuroimmunology (Center for Brain Research)
Position: PHD Student
Location: Spitalgasse 4
Telephone: 40160-34222
E-Mail:
Grant(s):
Abstract:
The focus of this project is to identify the phenotype of CNS-infiltrating B lineage cells and the antibody-repertoire expressed by these cells in CNS-autoimmune diseases. For that, we use archival brain tissues of patients suffering from multiple sclerosis or from MS-like diseases, like human autoimmune encephalitis. In one patient, we identified and cloned one fully functional antibody and are currently testing the pathogenic potential of this antibody in experimental models. This study was supported by a grant of the Austrian Science Fund DOC (FWF, project I3335-B27 and P28476-B30) and the German Research Council (DFG, DO420/3-1).
Techniques: