Department(s): Division of Pathobiology of the Nervous System (Center for Brain Research)
Position: Research Assistant
Birthday: 1st January
Location: Spitalgasse 4, first floor
Telephone: 40160-34094
E-Mail:
Research Area:
Peroxisomes in Brain Disorders
Research Interests:
Protein Transport, Metabolic Diseases, Adrenoleukodystrophy
Grant(s):
Abstract:
A variety of metabolic pathways are sequestered within peroxisomes. Thus, the participating enzymes and the metabolic substrates have to be imported into this organelle. The mechanisms mediating an efficient and specific transport of soluble and membrane proteins to peroxisomes are a major focus of interest. The transfer of small organic compounds across the peroxisomal membrane by specific transporter proteins and the metabolic interconversion of these compounds within peroxisomes are the second major focus. Both aspects are of medical importance, because a dysfunction in transport processes has been linked to human diseases such as X-linked adrenoleukodystrophy, Alzheimers disease or metabolic disorders.
Techniques:
Immunofluorescence Microscopy, Western Blot, Fluorescence Resonance Energy Transfer (FRET), Subcellular Fractionation, Density Gradient Centrifugation, Yeast Two Hybrid Assay, Mammalian Two Hybrid Assay, Immunoprecipitation, Cell Culture Techniques, PCR, qRT-PCR
Selected Publications:
