Department(s): Department of Neuroimmunology (Center for Brain Research)
Position: Professor
Location: Spitalgasse 4, A-1090 Vienna
Telephone: 40160-34200
E-Mail:
Further information: http://www.adameykolab.eu/
Download Curriculum vitae (CV)
Research Area:
Developmental Biology, Neurobiology, Neuroimmunology
Grant(s):
Abstract:
We are currently engaged in the discovery of multipotency of nerve-associated Schwann-cell precursors, a population of neural crest derived cells with exceptional plasticity and distribution in the body. These studies introduced a radically new concept for developmental biology in that defined precursor pools existing in a highly specialized niche use nerves as conduits to migrate and differentiate through temporally and spatially delineated nerve-Schwann cell communication. Can Schwann cells be genuinely multipotent? If so, this would transform the above discoveries into a global concept in which nerve-associated progenitors could generate various cell types during not only physiological development but also adulthood.
Techniques:
We extensively apply single cell transcriptomics analysis with an aim to discover the major principles of neural and immune cell type heterogeneity, stem cell regulation, evolution of novel cell types and transitions between gene regulatory networks. At the moment, we attempt to build a MERFISH system for spatial transcriptomics as well as to establish Slide-seq protocols in house.
Selected Publications:
