Department(s): Division of Molecular Neurosciences (Center for Brain Research)
Position: Professor
Location: Spitalgasse 4
Telephone: 40160-34050
E-Mail:
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Research Area:
Calcium, Diabetes Mellitus, Type 2, Endocannabinoids
Research Interests:
Synapses, Endocannabinoids, Developmental Biology, Child Development
Grant(s):
Abstract:
The nervous system consists of a kaleidoscope of molecularly distinct neurons and glial cells whose local, as well as long-distance communication underpin specific behaviors. We are interested in elucidating key developmental mechanisms that control the molecular diversification of neurons, and their activity-dependent integration in emergent neuronal networks. We are particularly interested in the study of how bioactive lipid signals orchestrate histogenesis via cell type-sepcific receptor systems. Moreover, we are studying the role of neuron-specific calcium-binding (sensor) proteins in neurons and neuroendocrine cells. Our work is expected to increase knowledge on the molecular pathobiology of prenatal cannabis exposure, epilepsy and diabetes.
Techniques:
Our repertoire of techniques include molecular biology, mouse genetics, neuroanatomy, protein biochemistry, electrophysiology and advanced imaging. Our laboratory has taken delivery of a number of state-of-the-art technical paltforms as first in Austria, including automated, laser-assisted Western blotting systems (GE) and a light-sheet microscope (Zeiss). We also employ tissue clearing protocols to appropriately resolve the morphological heterogeneity of neurons.
Selected Publications:
