Dominic Kargl, PhD

Department(s): Department of Neuronal Cell Biology (Center for Brain Research)
Position: Research Assistant
Birthday: 1st January
Location: Spitalgasse 4
E-Mail:

Research Area:
Neurosciences

Research Interests:
Psychiatry, Optogenetics, Neocortex, Electrophysiology, Association Learning, Afferent Pathways, Affect

Abstract:

I am interested in how our brain extracts meaning from the vast amount of sensory information in our environment. Sensing signals from the body,called interoception, isa deeply rootedsensory modality of the self. As such, it mayserve as aninternal reference for our brain to contextualize experiences coming in fromourexteroceptive sensesand determines how we feel about things.In my research, Iwant explorethe mechanisms that build such affective models and how they are used for meaningful adaptive behaviors. In a biomedical context, I would like to understand whether disturbance in these mechanisms may contribute to psychiatric disorders.

Techniques:

Chemogenetics, Optogenetics, In vivoelectrophysiology, Behavioral Phenotyping, Molecular biology

Selected Publications:

1. Piszczek L, Constantinescu A, Kargl D, Lazovic J, Pekcec A, Nicholson J, Haubensak W (2022) Dissociation of impulsive traits by subthalamic metabotropic glutamate receptor 4 eLife, 11
   | Weblink |
2. Peter M, Aschauer D F, Rose R, Sinning A, Grössl F, Kargl D, Kraitsy K, Burkard T R, Luhmann H J, Haubensak W, Rumpel S (2021) Rapid nucleus-scale reorganization of chromatin in neurons enables transcriptional adaptation for memory consolidation PlosOne, 16 (5): e0244038
   | Weblink |
3. Kargl D, Kaczanowska J, Ulonska S, Groessl F, Piszczek L, Lazovic J, Buehler K, Haubensak W (2020) The amygdala instructs insular feedback for affective learning eLife, 9
   | Weblink |
4. Griessner J, Pasieka M, Böhm V, Grössl F, Kaczanowska J, Pliota P, Kargl D, Werner B, Kaouane N, Strobelt S, Kreitz S, Hess A, Haubensak W (2018) Central amygdala circuit dynamics underlying the benzodiazepine anxiolytic effect Mol Psychiatry, 26 (2): 534-544
   | Weblink |
5. Groessl F, Munsch T, Meis S, Griessner J, Kaczanowska J, Pliota P, Kargl D, Badurek S, Kraitsy K, Rassoulpour A, Zuber J, Lessmann V, Haubensak W (2018) Dorsal tegmental dopamine neurons gate associative learning of fear Nature Neurosci, 21 (7): 952-962
   | Weblink |

Show all publications