Progressive degeneration of the dopaminergic nigro-striatal fibre system is the main neuropathological correlate of Parkinson's disease (PD). More recently, neurochemical changes have been described in other basal ganglia disorders either with overt parkinsonian symptomatology or responsive to L-DOPA (e.g. DOPA-Responsive-Dystonia). Changes in dopaminergic markers in animal models based on the neurotoxin MPTP suggest that the accumulation of endogenously formed, toxic dopamine transporter substrates such as isoquinoline or β-carboline derivatives, may represent the primary cause of substantia nigra cell degeneration specifically in patients with the idiopathic (most common) variety of PD.
Peneder et al (2011) Neurosci 180:280
Tong et al (2011) Neurobiol Dis 41:458
Ouattara et al (2011) Neurobiol Aging 32:1286
Hornykiewicz (2010) J Neurol 257:S249
Tong et al (2010) Brain 133:172 pdf
Boileau et al (2009) Brain 132:1366 pdf
Samadi et al (2009) J Neuropath Exp Neurol 68:374 pdf
Rajput et al (2008) Neurology 70:1403 pdf
Kish et al (2008) Brain 131:120 pdf
Tong et al (2007) J Neurochem 102:1691
Tong et al (2006) Arch Neurol 63:1724
Hornykiewicz (2006) J Neural Transm Suppl 70:9
Pifl & Hornykiewicz (2006) Neurochem Internat 49:519
Tong et al (2006) J Neurochem 96:349
Olanow et al (2004) Movement Disorders 19:997
Yamamoto & Hornykiewicz (2004) Prgr Neuro-PsyPharm & Biol Psy 28:913
Calon et al (2004) Brain 127:1075
Zecca et al (2004) Proc Nat Acad Sci 101:9843
Rajput et al (2004) Parkinsonism & Related Disorders 10:221
Haycock et al (2003) J Neurochem. 87:574
Calon et al (2003) Neurobiol Diseases 14:404
Calon et al (2003) Movement Disorders 18:241
Hornykiewicz (2002) Amino Acids 23:65
Hornykiewicz (2002) Movement Disorders 17:501
Calon et al (2002) J Neuropathol Exp Neurol 61:186
Rajput et al (2002) Movement Disorders 17:289
Tekumalla et al (2001) Biol Psychiatry 50:813
Hornykiewicz (2001) Wien Klin Wochenschr 113:855
Hornykiewicz (2001) J Chem Neuroanat. 22:3
Hornykiewicz (2001) Adv Neurol 86:1