Center for Brain Research

2017 Original Articles
o	Tong J, Rathitharan G, Meyer JH, Furukawa Y, Ang LC, Boileau I, Guttman M, Hornykiewicz O, Kish SJ (2017) Brain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders Brain, 140: 2460-2474
o	Pifl C, Reither H, Lopez-Gonzalez del Rey N, Cavada C, Obeso JA, Blesa J (2017) Early paradoxical increase of dopamine: A neurochemical study of olfactory bulb in asymptomatic and symptomatic MPTP treated monkeys Front Neuroanat, 11: 46
o	Ghafari M, Falsafi S, Szodorai E, Kim E, Li L, Höger H, Berger J, Fuchs K, Sieghart W, Lubec G (2017) Formation of GABAA receptor complexes containing α1 and α5 subunits is paralleling a multiple T-maze learning task in mice Brain Struct Funct, 222 (1): 549-561
o	Rivetti di Val Cervo P, Romanov RA, Spigolon G, Masini D, Martín-Montañez E, Toledo EM, La Manno G, Feyder M, Pifl C, Ng YH, Sánchez SP, Linnarsson S, Wernig M, Harkany T, Fisone G, Arenas E (2017) Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model Nat Biotechnol, 35: 444-452
o	Hornykiewicz O (2017) L-DOPA J Parkinson Dis, 7 (s1): S3-S10
o	Furlan A, Dyachuk V, Kastriti M, Calvo-Enrique L, Abdo H, Hadjab S, Chontorotzea T, Akkuratova N, Usoskin D, Kamenev D, Petersen J, Sunadome K, Memic F, Marklund U, Fried K, Topilko P, Lallemend F, Kharchenko P, Ernfors P, Adameyko I (2017) Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla Science, 357 (6346): eaal3753
o	Kaucka M, Zikmund T, Tesarova M, Gyllborg D, Hellander A, Jaros J, Kaiser J, Petersen J, Szarowska B, Newton P, Dyachuk V, Li L, Qian H, Johansson A, Mishina Y, Currie J, Tanaka E, Erickson A, Dudley A, Brismar H, Southam P, Coen E, Chen M, Weinstein L, Hampl A, Arenas E, Chagin A, Fried K, Adameyko I (2017) Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage eLife, 6:
o	Treven M, Siebert D, Holzinger R, Bampali K, Fabjan J, Varagic Z, Wimmer L, Steudle F, Scholze P, Schnürch M, Mihovilovic M, Ernst M (2017) Towards Functional Selectivity for α6β3γ2 GABAA Receptors: A Series of Novel Pyrazoloquinolinones Br J Pharmacol, 175 (3): 419-428
2016 Original Articles
o	Furukawa Y, Rajput A, Tong J, Tomizawa Y, Hornykiewicz O, Kish S (2016) A marked contrast between serotonergic and dopaminergic changes in dopa-responsive dystonia: Table Neurology, 87 (10): 1060-1061
o	Kaucka M, Ivashkin E, Gyllborg D, Zikmund T, Tesarova M, Kaiser J, Xie M, Petersen J, Pachnis V, Nicolis S, Yu T, Sharpe P, Arenas E, Brismar H, Blom H, Clevers H, Suter U, Chagin A, Fried K, Hellander A, Adameyko I (2016) Analysis of neural crest-derived clones reveals novel aspects of facial development Sci Adv, 2 (8): e1600060-e1600060 \| Article (PDF) \|\| Weblink \|
o	Peneder T, Bauer J, Pifl C (2016) Apoptosis-inducing factor in nigral dopamine neurons: Higher levels in primates than in mice Movement Disorders, 31: 1729-1733
o	Zhang MD, Barde S, Szodorai E, Josephson A, Mitsios N, Watanabe M, Attems J, Lubec G, Kovacs GM, Uhlen M, Mulder J, Harkany T, Hökfelt T (2016) Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord Brain Struct Funct, 221 (7): 3803-3823 \| Article (PDF) \|\| Weblink \|
o	Sitte HH, Pifl C, Rajput AH, Hörtnagl H, Tong J, Lloyd GK, Kish SJ, Hornykiewicz O (2016) Dopamine and noradrenaline, but not serotonin, in the human claustrum are greatly reduced in patients with Parkinson's disease: possible functional implications Eur J Neurosci, 45: 192-197
o	Jonas O, Calligaris D, Methuku K, Poe M, Francois J, Tranghese F, Changelian A, Sieghart W, Ernst M, Pomeranz Krummel D, Cook J, Pomeroy S, Cima M, Agar N, Langer R, Sengupta S (2016) First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development J Biomed Nanotech, 12 (6): 1297-1302
o	Hoerbelt P, Ramerstorfer J, Ernst M, Sieghart W, Thomson JL, Hough LB, Fleck MW (2016) Mutagenesis and computational docking studies support the existence of a histamine binding site at the extracellular b3+b3- interface of homooligomeric b3 GABA-A receptors Neuropharmacology, 108: 252-263
o	Adameyko I (2016) Neural circuitry gets rewired Science, 354 (6314): 833-834
o	Marques S, Zeisel A, Codeluppi S, van Bruggen D, Mendanha Falcao A, Xiao L, Li H, Haring M, Hochgerner H, Romanov R, Gyllborg D, Munoz-Manchado A, La Manno G, Lonnerberg P, Floriddia E, Rezayee F, Ernfors P, Arenas E, Hjerling-Leffler J, Harkany T, Richardson W, Linnarsson S, Castelo-Branco G (2016) Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system Science, 352 (6291): 1326-1329 \| Article (PDF) \|\| Weblink \|
o	Pifl C (2016) Problems with traffic ahead: Synaptic vesicles in Parkinson's disease Movement Disorders, 31: 1480
o	Berger ML (2016) Soaping the NMDA receptor: Various types of detergents influence differently [³H]MK-801 binding to rat brain membranes Biochim Biophys Acta, 1858: 116-122
o	Adameyko I, Fried K (2016) The Nervous System Orchestrates and Integrates Craniofacial Development: A Review Front Physiol, 7: \| Article (PDF) \|\| Weblink \|
2015 Original Articles
o	Hornykiewicz O (2015) 50 years of levodopa Movement Disorders, 30: 1008
o	Sieghart W (2015) Allosteric Modulation of GABAA Receptors via Multiple Drug-Binding Sites Adv Pharmacol, : 53-96
o	Alpár A, Di Marzo V, Harkany T (2015) At the Tip of an Iceberg: Prenatal Marijuana and Its Possible Relation to Neuropsychiatric Outcome in the Offspring Biol Psychiatry, :
o	Guggenhuber S, Alpar A, Chen R, Schmitz N, Wickert M, Mattheus T, Harasta AE, Purrio M, Kaiser N, Elphick MR, Monory K, Kilb W, Luhmann HJ, Harkany T, Lutz B, Klugmann M (2015) Cannabinoid receptor-interacting protein Crip 1a modulates CB1 receptor signaling in mouse hippocampus Brain Struct Funct, March 15: Epub ahead of print
o	Ádori C, Glück L, Barde S, Yoshitake T, Kovacs G, Mulder J, Maglóczky Z, Havas L, Bölcskei K, Mitsios N, Uhlén M, Szolcsányi J, Kehr J, Rönnbäck A, Schwartz T, Rehfeld J, Harkany T, Palkovits M, Schulz S, Hökfelt T (2015) Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer’s disease Acta Neuropathol, 129 (4): 541-563
o	Berger ML, Rebernik P (2015) Differential influence of 7 cations on 16 non-competitive NMDA receptor blockers Bioorg Med Chem Lett, 25 (19): 4131-4135 \| Article (PDF) \|\| Weblink \|
o	Pangratz-Fuehrer S, Sieghart W, Rudolph U, Parada I, Huguenard J (2015) Early postnatal switch in GABAAreceptor α-subunits in the reticular thalamic nucleus J. Neurophysiol., 115 (3): 1183-1195
o	Malenczyk K, Keimpema E, Piscitelli F, Calvigioni D, Björklund P, Mackie K, Di Marzo V, Hökfelt T, Dobrzyn A, Harkany T (2015) Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture PNAS, 112 (45): E6185-E6194
o	Ramerstorfer J, Foppa V, Thiery H, Hermange P, Janody S, Berger M, Dodd R, Sieghart W (2015) GABAA Receptor Subtype-Selectivity of Novel Bicuculline Derivates Curr Med Chem, 22: 771-780
o	Ernst M, Sieghart W (2015) GABAA receptor subtypes: structural variety raises hope for new therapy concepts e-Neuroforum, 6 (4): 97-103
o	Ernst M, Sieghart W (2015) GABAA – Rezeptorsubtypen: Strukturelle Vielfalt gibt Hoffnung auf neue Therapiekonzepte Neuroforum, 21 (4): 144-151
o	Tesoriero C, Codita A, Zhang M, Cherninsky A, Karlsson H, Grassi-Zucconi G, Bertini G, Harkany T, Ljungberg K, Liljeström P, Hökfelt T, Bentivoglio M, Kristensson K (2015) H1N1 influenza virus induces narcolepsy-like sleep disruption and targets sleep–wake regulatory neurons in mice PNAS, 113 (3): E368-E377
o	Fuzik J, Zeisel A, Máté Z, Calvigioni D, Yanagawa Y, Szabó G, Linnarsson S, Harkany T (2015) Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes Nat Biotechnol, 34 (2): 175-183
o	Bitencourt R, Alpár A, Cinquina V, Ferreira S, Pinheiro B, Lemos C, Ledent C, Takahashi R, Sialana F, Lubec G, Cunha R, Harkany T, Köfalvi A (2015) Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents Neurochem Internat, 90: 72-84
o	Tong J, Ang LC, Williams B, Furukawa Y, Fitzmaurice P, Guttman M, Boileau I, Hornykiewicz O, Kish SJ (2015) Low levels of astroglial markers in Parkinson's disease: relationship to alpha-synuclein accumulation Neurobiol Dis, 82: 243-253
o	Rycek L, Puthenkalam R, Schnürch M, Ernst M, Mihovilovic M (2015) Metal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABAA receptor ligands Bioorg Med Chem Lett, 25 (2): 400-403
o	Kudryavtsev D, Shelukhina I, Son L, Ojomoko L, Kryukova E, Lyukmanova E, Zhmak M, Dolgikh D, Ivanov I, Kasheverov I, Starkov V, Ramerstorfer J, Sieghart W, Tsetlin V, Utkin Y (2015) Neurotoxins from Snake Venoms and α-Conotoxin ImI Inhibit Functionally Active Ionotropic γ-Aminobutyric Acid (GABA) Receptors J Biol Chem, 290 (37): 22747-22758
o	Berger M, Maciejewska D, Vanden Eynde JJ, Mottamal M, Zabinski J, Kazmierczak P, Rezler M, Jarak I, Piantanida I, Karminski-Zamola G, Mayence A, Rebernik P, Kumar A, Ismail MA, Boykin DW, Huang TL (2015) Pentamidine analogs as iInhibitors of [3H]MK-801 and [3H]ifenprodil binding to rat brain NMDA receptors Bioorg Med Chem, 23 (15): 4489-4500 Article (PDF): 1 2 \|\| Weblink \|
o	Penz O, Fuzik J, Kurek A, Romanov R, Larson J, Park T, Harkany T, Keimpema E (2015) Protracted brain development in a rodent model of extreme longevity Sci Rep, 5: 11592 Article (PDF): 1 2 \|
o	Hnat J, Berger ML (2015) Radioligand kinetics at the NMDA receptor channel revisited: an active part by Na+ and Tris Neurotransmitter, 2: e 945
o	Valladolid-Acebes I, Daraio T, Brismar K, Harkany T, Ögren S, Hökfelt T, Bark C (2015) Replacing SNAP-25b with SNAP-25a expression results in metabolic disease PNAS, 112 (31): E4326-E4335
o	Ivashkin E, Khabarova M, Melnikova V, Nezlin LP, Kharchenko O, Voronezhskaya EE, Adameyko I (2015) Serotonin Mediates Maternal Effects and Directs Developmental and Behavioral Changes in the Progeny of Snails Cell Rep, 12 (7): 1144-1158 \| Article (PDF) \|\| Weblink \|
o	Yocum GT, Gallos G, Zhang Y, Jahan R, Stephen MR, Varagic Z, Puthenkalam R, Ernst M, Cook JM, Emala CW (2015) Targeting the GABAA Receptor α4 Subunit in Airway Smooth Muscle to Alleviate Bronchoconstriction Am J Respir Cell Mol Biol, Sept 25: Epub ahead of print
o	Karabacak Y, Sase S, Aher YD, Sase A, Saroja SR, Cicvaric A, Höger H, Berger M, Bakulev V, Sitte HH, Leban J, Monje FJ, Lubec G (2015) The effect of modafinil on the rat dopamine transporter and dopamine receptors D1-D3 paralleling cognitive enhancement in the radial arm maze Front Behav Neurosci, Epub August 2015:
o	Pifl C, Reither H, Hornykiewicz O (2015) The profile of mephedrone on human monoamine transporters differs from 3,4-methylenedioxymethamphetamine primarily by lower potency at the vesicular monoamine transporter Eur J Pharmacol, 755: 119-126 \| Article (PDF) \|
2014 Original Articles
o	Carta V, Pangerl M, Baur R, Puthenkalam R, Ernst M, Trauner D, Sigel E (2014) A Pentasymmetric Open Channel Blocker for Cys-Loop Receptor Channels PLoS One, 9 (9): e106688
o	Romanov R, Alpar A, Zhang M, Zeisel A, Calas A, Landry M, Fuszard M, Shirran SL, Schnell R, Dobolyi A, Olah M, Spence L, Mulder J, Martens H, Palkovits M, Uhlen M, Sitte H, Botting CH, Wagner L, Linnarsson S, Hökfelt T, Harkany T (2014) A secretagonin locus of the mammalian hypothalamus controls stress hormon release EMBO J., 34 (1): 36-54 \| Article (PDF) \|
o	Middendorp S, Puthenkalam R, Baur R, Ernst M, Sigel E (2014) Accelerated Discovery of Novel Benzodiazepine Ligands by Experiment-Guided Virtual Screening ACS Chem Biol, 9 (8): 1854-1859
o	Parnia S, Spearpoint K, de Vos G, Fenwick P, Goldberg D, Yang J, Zhu J, Baker K, Killingback H, Beisteiner R, Berger M, Bullock S, Sutton J, Walmsley A, Deakin CD, Little P, Farber M, Greyson B, Schoenfeld ER (2014) AWARE-AWAREness during REsuscitation-A prospective study Resuscitation, 85: 1799-1805
o	Kaukua N, Shahidi M, Konstantinidou C, Dyachuk V, Kaucka M, Furlan A, An Z, Wang L, Hultman I, Ährlund-Richter L, Blom H, Brismar H, Lopes N, Pachnis V, Suter U, Clevers H, Thesleff I, Sharpe P, Ernfors P, Fried K, Adameyko I (2014) Glial origin of mesenchymal stem cells in a tooth model system Nature, 513 (7519): 551-554
o	Pifl C, Rajput A, Reither H, Blesa J, Cavada C, Obeso JA, Rajput AH, Hornykiewicz O (2014) Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum J Neurosci, 24: 8210-8218
o	Tortoriello G, Morris CV, Alpar A, Fuzik J, Shirran SL, Calvigioni D, Keimpema E, Botting CH, Reinecke K, Herdegen T, Courtney M, Hurd YL, Harkany T (2014) Miswiring the brain: delta9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway Embo Journ, : published online 27.01.2014
o	Zhang M, Tortoriello G, Hsueh B, Tomer R, Ye L, Mitsios N, Borgius L, Grant G, Kiehn O, Watanabe M, Uhlen M, Mulder J, Deisseroth K, Harkany T, Hökfelt T (2014) Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury PNAS, 111 (12): E1149-E1158
o	Calvigioni D, Hurd YL, Harkany T, Keimpema E, (2014) Neuronal substrates and functional consequences of prenatal cannabis exposure Child Adolesc Psychiatry Ment Health, Epub May 3, 2014:
o	Harkany T, Zeilhofer HU, Cattaneo A (2014) Neurotrophin and endocannabinoid interactions in the neurobiology of pain Eur J Neurosci, 39: 331-333
o	Dyachuk V, Furlan A, Shahidi M, Giovenco M, Kaukua N, Konstantinidou C, Pachnis V, Memic F, Marklund U, Muller T, Birchmeier C, Fried K, Ernfors P, Adameyko I (2014) Parasympathetic neurons originate from nerve-associated peripheral glial progenitors Science, 345 (6192): 82-87
o	Ferreira SG, Goncalves FQ, Marques JM, Tomé AR, Rodrigues RJ, Nunes-Correia I, Ledent C, Harkany T, Venance L, Cunha RA, Köfalvi A (2014) Presynaptic A2A adenosine receptors dampen CB1 cannabinoid receptor-mediated inhibition of corticostriatal glutamatergic transmission Br J Pharmacol, Oct 9:
o	Maccarrone M, Guzman M, Mackie K, Doherty P, Harkany T (2014) Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies Nat. Rev. Neurosci., 15: 786-801
o	Gati G, Lendvai D, Hökfelt T, Harkany T, Alpar A (2014) Revival of calcium-binding proteins for neuromorphology: secretagonin typifies distinct cell populations in the avian brain Brain Behav Evol, Epub April 24. 2014:
o	Obradović A, Joksimović S, Poe M, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth B, Sieghart W, Cook J, Savić M (2014) Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: The approximated activation of receptor subtypes may explain behavioral effects Brain Res, 1554: 36-48
o	Iannotti FA, Silvestri C, Mazzarella E, Martella A, Calvigioni D, Piscitelli F, Ambrosino P, Petrosino S, Czifra G, Biro T, Harkany T, Taglialatela M, Di Marzo V (2014) The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels Proc Natl Acad Sci USA, Epub June 3, 2014:
o	Iannotti F, Silvestri C, Mazzarella E, Martella A, Calvigioni D, Piscitelli F, Ambrosino P, Petrosino S, Czifra G, Biro T, Harkany T, Taglialatela M, Di Marzo V (2014) The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels PNAS, 111 (24): E2472-E2481
o	Mirheydari P, Ramerstorfer J, Varagic Z, Scholze P, Wimmer L, Mihovilovic MM, Sieghart W, Ernst M (2014) Unexpected properties of delta-containing GABA-A receptors in response to ligands interacting with the alpha+beta-site Neurochem Res, 39 (6): 1057-1067
2014 Reviews
o	Keimpema E, Hökfelt T, Harkany T, Doherty P (2014) The molecular interplay between endocannabinoid and neurotrophin signals in the nervous system and beyond Eur J Neurosci, 39: 334-343
2014 Book Chapters
o	Sieghart W (2014) GABA-A receptors in the brain: exciting targets for the development of clinically important drugs. In: (Eds.), Magyar Tudomanyos Akademia k.A.: k.A.