Center for Brain Research

2017 Original Articles
o	Pifl C, Reither H, Lopez-Gonzalez del Rey N, Cavada C, Obeso JA, Blesa J (2017) Early paradoxical increase of dopamine: A neurochemical study of olfactory bulb in asymptomatic and symptomatic MPTP treated monkeys Front Neuroanat, 11: 46
o	Rivetti di Val Cervo P, Romanov RA, Spigolon G, Masini D, Martín-Montañez E, Toledo EM, La Manno G, Feyder M, Pifl C, Ng YH, Sánchez SP, Linnarsson S, Wernig M, Harkany T, Fisone G, Arenas E (2017) Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model Nat Biotechnol, 35: 444-452
2016 Original Articles
o	Furukawa Y, Rajput A, Tong J, Tomizawa Y, Hornykiewicz O, Kish S (2016) A marked contrast between serotonergic and dopaminergic changes in dopa-responsive dystonia: Table Neurology, 87 (10): 1060-1061
o	Kaucka M, Ivashkin E, Gyllborg D, Zikmund T, Tesarova M, Kaiser J, Xie M, Petersen J, Pachnis V, Nicolis S, Yu T, Sharpe P, Arenas E, Brismar H, Blom H, Clevers H, Suter U, Chagin A, Fried K, Hellander A, Adameyko I (2016) Analysis of neural crest-derived clones reveals novel aspects of facial development Sci Adv, 2 (8): e1600060-e1600060 \| Article (PDF) \|\| Weblink \|
o	Peneder T, Bauer J, Pifl C (2016) Apoptosis-inducing factor in nigral dopamine neurons: Higher levels in primates than in mice Movement Disorders, 31: 1729-1733
o	Zhang MD, Barde S, Szodorai E, Josephson A, Mitsios N, Watanabe M, Attems J, Lubec G, Kovacs GM, Uhlen M, Mulder J, Harkany T, Hökfelt T (2016) Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord Brain Struct Funct, 221 (7): 3803-3823 \| Article (PDF) \|\| Weblink \|
o	Sitte HH, Pifl C, Rajput AH, Hörtnagl H, Tong J, Lloyd GK, Kish SJ, Hornykiewicz O (2016) Dopamine and noradrenaline, but not serotonin, in the human claustrum are greatly reduced in patients with Parkinson's disease: possible functional implications Eur J Neurosci, 45: 192-197
o	Jonas O, Calligaris D, Methuku K, Poe M, Francois J, Tranghese F, Changelian A, Sieghart W, Ernst M, Pomeranz Krummel D, Cook J, Pomeroy S, Cima M, Agar N, Langer R, Sengupta S (2016) First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development J Biomed Nanotech, 12 (6): 1297-1302
o	Ghafari M, Falsafi S, Szodorai E, Kim E, Li L, Höger H, Berger J, Fuchs K, Sieghart W, Lubec G (2016) Formation of GABAA receptor complexes containing α1 and α5 subunits is paralleling a multiple T-maze learning task in mice Brain Struct Funct, 222 (1): 549-561
o	Hoerbelt P, Ramerstorfer J, Ernst M, Sieghart W, Thomson JL, Hough LB, Fleck MW (2016) Mutagenesis and computational docking studies support the existence of a histamine binding site at the extracellular b3+b3- interface of homooligomeric b3 GABA-A receptors Neuropharmacology, 108: 252-263
o	Marques S, Zeisel A, Codeluppi S, van Bruggen D, Mendanha Falcao A, Xiao L, Li H, Haring M, Hochgerner H, Romanov R, Gyllborg D, Munoz-Manchado A, La Manno G, Lonnerberg P, Floriddia E, Rezayee F, Ernfors P, Arenas E, Hjerling-Leffler J, Harkany T, Richardson W, Linnarsson S, Castelo-Branco G (2016) Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system Science, 352 (6291): 1326-1329 \| Article (PDF) \|\| Weblink \|
o	Pifl C (2016) Problems with traffic ahead: Synaptic vesicles in Parkinson's disease Movement Disorders, 31: 1480
o	Berger ML (2016) Soaping the NMDA receptor: Various types of detergents influence differently [³H]MK-801 binding to rat brain membranes Biochim Biophys Acta, 1858: 116-122
o	Adameyko I, Fried K (2016) The Nervous System Orchestrates and Integrates Craniofacial Development: A Review Front Physiol, 7: \| Article (PDF) \|\| Weblink \|
2015 Original Articles
o	Hornykiewicz O (2015) 50 years of levodopa Movement Disorders, 30: 1008
o	Sieghart W (2015) Allosteric Modulation of GABAA Receptors via Multiple Drug-Binding Sites Adv Pharmacol, : 53-96
o	Alpár A, Di Marzo V, Harkany T (2015) At the Tip of an Iceberg: Prenatal Marijuana and Its Possible Relation to Neuropsychiatric Outcome in the Offspring Biol Psychiatry, :
o	Guggenhuber S, Alpar A, Chen R, Schmitz N, Wickert M, Mattheus T, Harasta AE, Purrio M, Kaiser N, Elphick MR, Monory K, Kilb W, Luhmann HJ, Harkany T, Lutz B, Klugmann M (2015) Cannabinoid receptor-interacting protein Crip 1a modulates CB1 receptor signaling in mouse hippocampus Brain Struct Funct, March 15: Epub ahead of print
o	Ádori C, Glück L, Barde S, Yoshitake T, Kovacs G, Mulder J, Maglóczky Z, Havas L, Bölcskei K, Mitsios N, Uhlén M, Szolcsányi J, Kehr J, Rönnbäck A, Schwartz T, Rehfeld J, Harkany T, Palkovits M, Schulz S, Hökfelt T (2015) Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer’s disease Acta Neuropathol, 129 (4): 541-563
o	Berger ML, Rebernik P (2015) Differential influence of 7 cations on 16 non-competitive NMDA receptor blockers Bioorg Med Chem Lett, 25 (19): 4131-4135 \| Article (PDF) \|\| Weblink \|
o	Pangratz-Fuehrer S, Sieghart W, Rudolph U, Parada I, Huguenard J (2015) Early postnatal switch in GABAAreceptor α-subunits in the reticular thalamic nucleus J. Neurophysiol., 115 (3): 1183-1195
o	Malenczyk K, Keimpema E, Piscitelli F, Calvigioni D, Björklund P, Mackie K, Di Marzo V, Hökfelt T, Dobrzyn A, Harkany T (2015) Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture PNAS, 112 (45): E6185-E6194
o	Ramerstorfer J, Foppa V, Thiery H, Hermange P, Janody S, Berger M, Dodd R, Sieghart W (2015) GABAA Receptor Subtype-Selectivity of Novel Bicuculline Derivates Curr Med Chem, 22: 771-780
o	Ernst M, Sieghart W (2015) GABAA receptor subtypes: structural variety raises hope for new therapy concepts e-Neuroforum, 6 (4): 97-103
o	Ernst M, Sieghart W (2015) GABAA – Rezeptorsubtypen: Strukturelle Vielfalt gibt Hoffnung auf neue Therapiekonzepte Neuroforum, 21 (4): 144-151
o	Tesoriero C, Codita A, Zhang M, Cherninsky A, Karlsson H, Grassi-Zucconi G, Bertini G, Harkany T, Ljungberg K, Liljeström P, Hökfelt T, Bentivoglio M, Kristensson K (2015) H1N1 influenza virus induces narcolepsy-like sleep disruption and targets sleep–wake regulatory neurons in mice PNAS, 113 (3): E368-E377
o	Fuzik J, Zeisel A, Máté Z, Calvigioni D, Yanagawa Y, Szabó G, Linnarsson S, Harkany T (2015) Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes Nat Biotechnol, 34 (2): 175-183
o	Bitencourt R, Alpár A, Cinquina V, Ferreira S, Pinheiro B, Lemos C, Ledent C, Takahashi R, Sialana F, Lubec G, Cunha R, Harkany T, Köfalvi A (2015) Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents Neurochem Internat, 90: 72-84
o	Tong J, Ang LC, Williams B, Furukawa Y, Fitzmaurice P, Guttman M, Boileau I, Hornykiewicz O, Kish SJ (2015) Low levels of astroglial markers in Parkinson's disease: relationship to alpha-synuclein accumulation Neurobiol Dis, 82: 243-253
o	Rycek L, Puthenkalam R, Schnürch M, Ernst M, Mihovilovic M (2015) Metal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABAA receptor ligands Bioorg Med Chem Lett, 25 (2): 400-403
o	Kudryavtsev D, Shelukhina I, Son L, Ojomoko L, Kryukova E, Lyukmanova E, Zhmak M, Dolgikh D, Ivanov I, Kasheverov I, Starkov V, Ramerstorfer J, Sieghart W, Tsetlin V, Utkin Y (2015) Neurotoxins from Snake Venoms and α-Conotoxin ImI Inhibit Functionally Active Ionotropic γ-Aminobutyric Acid (GABA) Receptors J Biol Chem, 290 (37): 22747-22758
o	Berger M, Maciejewska D, Vanden Eynde JJ, Mottamal M, Zabinski J, Kazmierczak P, Rezler M, Jarak I, Piantanida I, Karminski-Zamola G, Mayence A, Rebernik P, Kumar A, Ismail MA, Boykin DW, Huang TL (2015) Pentamidine analogs as iInhibitors of [3H]MK-801 and [3H]ifenprodil binding to rat brain NMDA receptors Bioorg Med Chem, 23 (15): 4489-4500 Article (PDF): 1 2 \|\| Weblink \|
o	Penz O, Fuzik J, Kurek A, Romanov R, Larson J, Park T, Harkany T, Keimpema E (2015) Protracted brain development in a rodent model of extreme longevity Sci Rep, 5: 11592 Article (PDF): 1 2 \|
o	Hnat J, Berger ML (2015) Radioligand kinetics at the NMDA receptor channel revisited: an active part by Na+ and Tris Neurotransmitter, 2: e 945
o	Valladolid-Acebes I, Daraio T, Brismar K, Harkany T, Ögren S, Hökfelt T, Bark C (2015) Replacing SNAP-25b with SNAP-25a expression results in metabolic disease PNAS, 112 (31): E4326-E4335
o	Ivashkin E, Khabarova M, Melnikova V, Nezlin LP, Kharchenko O, Voronezhskaya EE, Adameyko I (2015) Serotonin Mediates Maternal Effects and Directs Developmental and Behavioral Changes in the Progeny of Snails Cell Rep, 12 (7): 1144-1158 \| Article (PDF) \|\| Weblink \|
o	Yocum GT, Gallos G, Zhang Y, Jahan R, Stephen MR, Varagic Z, Puthenkalam R, Ernst M, Cook JM, Emala CW (2015) Targeting the GABAA Receptor α4 Subunit in Airway Smooth Muscle to Alleviate Bronchoconstriction Am J Respir Cell Mol Biol, Sept 25: Epub ahead of print
o	Karabacak Y, Sase S, Aher YD, Sase A, Saroja SR, Cicvaric A, Höger H, Berger M, Bakulev V, Sitte HH, Leban J, Monje FJ, Lubec G (2015) The effect of modafinil on the rat dopamine transporter and dopamine receptors D1-D3 paralleling cognitive enhancement in the radial arm maze Front Behav Neurosci, Epub August 2015:
o	Pifl C, Reither H, Hornykiewicz O (2015) The profile of mephedrone on human monoamine transporters differs from 3,4-methylenedioxymethamphetamine primarily by lower potency at the vesicular monoamine transporter Eur J Pharmacol, 755: 119-126 \| Article (PDF) \|
2014 Original Articles
o	Carta V, Pangerl M, Baur R, Puthenkalam R, Ernst M, Trauner D, Sigel E (2014) A Pentasymmetric Open Channel Blocker for Cys-Loop Receptor Channels PLoS One, 9 (9): e106688
o	Romanov R, Alpar A, Zhang M, Zeisel A, Calas A, Landry M, Fuszard M, Shirran SL, Schnell R, Dobolyi A, Olah M, Spence L, Mulder J, Martens H, Palkovits M, Uhlen M, Sitte H, Botting CH, Wagner L, Linnarsson S, Hökfelt T, Harkany T (2014) A secretagonin locus of the mammalian hypothalamus controls stress hormon release EMBO J., 34 (1): 36-54 \| Article (PDF) \|
o	Middendorp S, Puthenkalam R, Baur R, Ernst M, Sigel E (2014) Accelerated Discovery of Novel Benzodiazepine Ligands by Experiment-Guided Virtual Screening ACS Chem Biol, 9 (8): 1854-1859
o	Parnia S, Spearpoint K, de Vos G, Fenwick P, Goldberg D, Yang J, Zhu J, Baker K, Killingback H, Beisteiner R, Berger M, Bullock S, Sutton J, Walmsley A, Deakin CD, Little P, Farber M, Greyson B, Schoenfeld ER (2014) AWARE-AWAREness during REsuscitation-A prospective study Resuscitation, 85: 1799-1805
o	Pifl C, Rajput A, Reither H, Blesa J, Cavada C, Obeso JA, Rajput AH, Hornykiewicz O (2014) Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum J Neurosci, 24: 8210-8218
o	Tortoriello G, Morris CV, Alpar A, Fuzik J, Shirran SL, Calvigioni D, Keimpema E, Botting CH, Reinecke K, Herdegen T, Courtney M, Hurd YL, Harkany T (2014) Miswiring the brain: delta9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway Embo Journ, : published online 27.01.2014
o	Zhang M, Tortoriello G, Hsueh B, Tomer R, Ye L, Mitsios N, Borgius L, Grant G, Kiehn O, Watanabe M, Uhlen M, Mulder J, Deisseroth K, Harkany T, Hökfelt T (2014) Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury PNAS, 111 (12): E1149-E1158
o	Calvigioni D, Hurd YL, Harkany T, Keimpema E, (2014) Neuronal substrates and functional consequences of prenatal cannabis exposure Child Adolesc Psychiatry Ment Health, Epub May 3, 2014:
o	Harkany T, Zeilhofer HU, Cattaneo A (2014) Neurotrophin and endocannabinoid interactions in the neurobiology of pain Eur J Neurosci, 39: 331-333
o	Ferreira SG, Goncalves FQ, Marques JM, Tomé AR, Rodrigues RJ, Nunes-Correia I, Ledent C, Harkany T, Venance L, Cunha RA, Köfalvi A (2014) Presynaptic A2A adenosine receptors dampen CB1 cannabinoid receptor-mediated inhibition of corticostriatal glutamatergic transmission Br J Pharmacol, Oct 9:
o	Maccarrone M, Guzman M, Mackie K, Doherty P, Harkany T (2014) Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies Nat. Rev. Neurosci., 15: 786-801
o	Gati G, Lendvai D, Hökfelt T, Harkany T, Alpar A (2014) Revival of calcium-binding proteins for neuromorphology: secretagonin typifies distinct cell populations in the avian brain Brain Behav Evol, Epub April 24. 2014:
o	Obradović A, Joksimović S, Poe M, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth B, Sieghart W, Cook J, Savić M (2014) Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: The approximated activation of receptor subtypes may explain behavioral effects Brain Res, 1554: 36-48
o	Iannotti FA, Silvestri C, Mazzarella E, Martella A, Calvigioni D, Piscitelli F, Ambrosino P, Petrosino S, Czifra G, Biro T, Harkany T, Taglialatela M, Di Marzo V (2014) The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels Proc Natl Acad Sci USA, Epub June 3, 2014:
o	Iannotti F, Silvestri C, Mazzarella E, Martella A, Calvigioni D, Piscitelli F, Ambrosino P, Petrosino S, Czifra G, Biro T, Harkany T, Taglialatela M, Di Marzo V (2014) The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels PNAS, 111 (24): E2472-E2481
o	Mirheydari P, Ramerstorfer J, Varagic Z, Scholze P, Wimmer L, Mihovilovic MM, Sieghart W, Ernst M (2014) Unexpected properties of delta-containing GABA-A receptors in response to ligands interacting with the alpha+beta-site Neurochem Res, 39 (6): 1057-1067
2014 Reviews
o	Keimpema E, Hökfelt T, Harkany T, Doherty P (2014) The molecular interplay between endocannabinoid and neurotrophin signals in the nervous system and beyond Eur J Neurosci, 39: 334-343
2014 Book Chapters
o	Sieghart W (2014) GABA-A receptors in the brain: exciting targets for the development of clinically important drugs. In: (Eds.), Magyar Tudomanyos Akademia k.A.: k.A.
2013 Original Articles
o	Baur R, Kielar M, Richter L, Ernst M, Ecker G, Sigel E (2013) Molecular analysis of the site for 2-arachidonylglycerol (2-AG) on the β 2 subunit of GABA A receptors J Neurochem, 126 (1): 29-36
o	Yip GM, Chen ZW, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS, Fanks NP (2013) A propofol binding site on mammalian GABA-A receptors identified by photolabeling Nature Chem Biol, 9: 715-720
o	Sieghart W (2013) Anxioselective anxiolytics: additional perspective Trends Pharmacol Sci, 34: 145-146
o	Malenczyk K, Jazurek M, Keimpema E, Silvestri C, Janikiewicz J, Mackie K, Di Marzo V, Redowicz MJ, Harkany T, Dobrzyn A (2013) CB1 Cannabinoid Receptors Couple to Focal Adhesion Kinase to Control Insulin Release J Biol Chem, 288: 32685-32699
o	Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Mimata H, Yoshimura A, Tamir I, Herbst R, Martinez J, Penninger JM et al. (2013) CLP1 links tRNA metabolism to progressive motor-neuron loss Nature, 495 (7442): 474-480 \| Weblink \|
o	Mark C, Bornatowicz B, Mitterhauser M, Hendl M, Nics L, Haeusler D, Lanzenberger R, Berger ML, Spreizer H, Wadsak W (2013) Development and automation of a novel NET-PET tracer: [11C]Me@APPI Nucl Med and Biol, 40: 295-303
o	Palangsuntikul R, Berner H, Berger ML,Wolschann P (2013) Holographic Quantitative Structure-Activity Relationships of Tryptamine Derivatives at NMDA, 5HT-1A and 5HT-2A Receptors Molecules, 18: 8799-8811
o	Varagic Z, Wimmer L, Schnuerch M, Mihovilovic MD, Huang S, Rallapalli S, Cook JM, Mirheydari P, Ecker GF, Sieghart W, Ernst M (2013) Identification of novel positive allosteric modulators and null modulators at the GABA-a receptor alpha+beta-interface Br J Pharmacol, 169(2): 371-383
o	Joksimovic S, Varagic Z, Kovacevic J, Van Linn M, Milic M, Rallapali S, Timic T, Sieghart W, Cook JM, Savic MM (2013) Insights into functional pharmacology of alpha1 GABA-A receptors: how much does partial activation at the benzodiazepine site matter? Psychopharmycol, 230: 113-123
o	Keimpema E, Tortoriello G, Alpar A, Capsoni S, Arisi I, Calvigioni D, Hu S, Cattaneo A, Doherty P, Mackie K, Harkany T (2013) Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons PNAS, 110: 1935-1940
o	Hoertnagl H, Tasan RO, Wieselthaler A, Kirchmair E, Sieghart W, Sperk G (2013) Patterns of mRNA and protein expression for 12 GABA-A receptor subunits in the mouse brain Neuroscience, 236: 345-372
o	Pifl C, Hornykiewicz O, Blesa J, Adanez R, Cavada C, Obeso JA (2013) Reduced noradrenaline, but not dopamine and serotonin in motor thalamus of the MPTP primate: relation to severity of Parkinsonism J Neurochem, 125: 657-662
o	Namjoshi OA, Wang Z-J, Rallapalli SK, Johnson EM Jr, Johnson Y-T, Ng H, Ramerstorfer J, Varagic Z, Sieghart W, Majumder S, Roth BL, Rowlett JK, Cook JM (2013) Search for alpha3beta2/3gamma2 subtype selective ligands that are stableon human liver microsomes Bioorg Med Chem, 21: 93-101
o	Varagic Z, Ramerstorfer J, Huang S, Rallapalli S, Sarto-Jackson I, Cook J, Sieghart W, Ernst M (2013) Subtype selectivity of alpha+beta-site ligands of GABA-A receptors - identification of the first highly specific positive modulators at alpha6beta2/3gamma2 receptors Br J Pharmacol, 169(2): 384-399
o	Milenkovic I, Vasiljevic M, Maurer D, Höger H, Klausberger T, Sieghart W. (2013) The parvalbumin-positive interneurons in the mouse dentate gyrus express GABAA receptor subunits alpha1, beta2, and delta along their extrasynaptic cell membrane. Neuroscience, 254: 80-96 \| Weblink \|
o	Berger ML, Hammerschmidt F, Qian R, Hahner S, Schirbel A, Stichelberger M, Schibli R, Yu J, Arion VB, Woschek A, Öhler E, Zolle IM (2013) [3H]Metyrapol and 4-[131I]Iodometomidate Label Overlapping, but Not Identical, Binding Sites on Rat Adrenal Membranes Mol Pharmaceutics, 10: 1119-1130 \| Article (PDF) \|
2013 Reviews
o	Keimpema E, Calvigioni D, Harkany T (2013) Endocannabinoid signals in the developmental programming of delayed-onset neuropsychiatric and metabolic illnesses Biochem. Soc. Trans., 41: 1569-1576